局部晚期结肠癌术前化疗的研究进展
Advance in preoperative chemotherapy for locally advanced colon cancer
摘 要
局部晚期结肠癌患者手术后复发率高，预后较差，亟待提高患者的生存质量。研究表明，更早的全身治疗可有效根除肿瘤微转移，降低肿瘤复发和转移风险。术前化疗作为全身治疗的一种，在胃癌、乳腺癌及食管癌的治疗中被证明有效，但术前化疗在局部晚期结肠癌中的疗效尚不明确。为探索术前化疗在局部晚期结肠癌中的可行性及有效性，探讨局部晚期结肠癌的治疗策略，本综述重点探讨局部晚期结肠癌患者实施术前化疗的理论基础及临床疗效、CT作为一种有效手段用于筛选符合术前化疗标准的患者并评价术前化疗的疗效，以及结肠癌术前化疗未来研究的方向。
药物疗法
预后
体层摄影术，螺旋计算机
Colonic neoplasms
Drug therapy
Prognosis
Tomography, spiral computed
Abstract
The patients with locally advanced colon cancer have high recurrence rate and poor prognosis after operation, so their quality of life needs to be improved. The present studies show that the early systemic treatment is able to eradicate tumor micrometastasis effectively and reduce the risks of tumor recurrence and metastasis. Preoperative chemotherapy as a kind of systemic treatment is effective for gastric cancer, breast cancer and esophageal cancer, but its curative effect on locally advanced colon cancer is not clear. To explore the feasibility and effectiveness of preoperative chemotherapy for the locally advanced colon cancer and to discuss the treatment strategy of locally advanced colon cancer, this review focuses on the theoretical basis and the clinical efficacy of preoperative chemotherapy for the patients with locally advanced colon cancer, and CT as a mean of screening the patients with preoperative chemotherapy standards and evaluating the curative effect of preoperative chemotherapy, as well as the future research directions of preoperative chemotherapy for colon cancer.
中图分类号 R735.35 DOI 10.3781/j.issn.1000-7431.2018.55.065
所属栏目 综述
基金项目 河北省科技计划项目（编号：14277710D）
收稿日期 2018/1/22
修改稿日期 2018/3/7
网络出版日期
作者单位点击查看
引用该论文: WANG Guanglin,MENG Zesong,WANG Feifei,WANG Guiying. Advance in preoperative chemotherapy for locally advanced colon cancer[J]. Tumor, 2018, 38(7): 716～721
王光林,孟泽松,王飞飞,王贵英. 局部晚期结肠癌术前化疗的研究进展[J]. 肿瘤, 2018, 38(7): 716～721
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参考文献
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【2】TORRE A, BRAY F, SIEGEL RL, et al. Global cancer statistics, 2012[J]. CA Cancer J Clin, 2015, 65(2):87-108.
【3】MOUTINHO C, MARTINEZ-CARDUS A, SANTOS C, et al. Epigenetic inactivation of the BRCA1 interactor SRBC and resistance to oxaliplatin in colorectal cancer[J]. J Natl Cancer Inst, 2014. 106(1):djt322.
【4】JEON Y, KIM TH, YOUN HJ, et al. A multicenter phaseⅡ trial of neoadjuvant chemotherapy with docetaxel and gemcitabine in locally advanced breast cancer[J]. J Breast Cancer, 2017, 20(4):340-346.
【5】TSUBURAYA A, NAGATA N, CHO H, et al. PhaseⅡ trial of paclitaxel and cisplatin as neoadjuvant chemotherapy for locally advanced gastric cancer[J]. Cancer Chemother Pharmacol, 2013, 71(5):1309-1314.
【6】LORUSSO D, RAMONDINO S, Mancini M, et al. PhaseⅡ trial on cisplatin-adriamycin-paclitaxel combination as neoadjuvant chemotherapy for locally advanced cervical adenocarcinoma[J]. Int J Gynecol Cancer, 2014, 24(4):729-734.
【7】NORDLINGER B, SORBYE H, GLIMELIUS B, et al. Perioperative chemotherapy with FOLFOX4 and surgery versus surgery alone for resectable liver metastases from colorectal cancer (EORTC Intergroup trial 40983): a randomised controlled trial[J]. Lancet, 2008, 371(9617):1007-1016.
【8】XU, Q, XU Y, SUN H, et al. Quantitative intravoxel incoherent motion parameters derived from whole-tumor volume for assessing pathological complete response to neoadjuvant chemotherapy in locally advanced rectal cancer[J]. J Magn Reson Imaging, 2018, 48(1):248-258.
【9】HASEGAWA S, GOTO S, MATSUMOTO T, et al. A Multicenter phase 2 study on the feasibility and efficacy of neoadjuvant chemotherapy without radiotherapy for locally advanced rectal cancer[J]. Ann Surg Oncol, 2017, 24(12):3587-3595.
【10】ZHOU H, SONG Y, JIANG J, et al. A pilot phase Ⅱ study of neoadjuvant triplet chemotherapy regimen in patients with locally advanced resectable colon cancer[J]. Chin J Cancer Res, 2016. 28(6):598-605.
【11】CUKIER M, SMITH AJ, MILOT L, et al. Neoadjuvant chemoradiotherapy and multivisceral resection for primary locally advanced adherent colon cancer: a single institution experience[J]. Eur J Surg Oncol, 2012, 38(8):677-682.
【12】吴卫东, 邢同海. 术前化疗后结直肠癌组织中Fas/FasL和survivin的表达[J]. 肿瘤, 2006, 26(1):85-87.
【13】ARREDONDO J, GONZALEZ I, BAIXAULI J, et al. Tumor response assessment in locally advanced colon cancer after neoadjuvant chemotherapy[J]. J Gastrointest Oncol, 2014, 5(2):104-111.
【14】DAM C, LUND-RASMUSSEN V, PLOEN J, et al. Computed tomography assessment of early response to neoadjuvant therapy in colon cancer. Dan Med J, 2015, 62(7): A5103.
【15】JAKOBSEN A, ANDERSEN F, FISCHER A, et al. Neoadjuvant chemotherapy in locally advanced colon cancer. A phaseⅡtrial[J]. Acta Oncol, 2015, 54(10):1747-1753.
【16】ARREDONDO J, BAIXAULI J, PASTOR C, et al. Mid-term oncologic outcome of a novel approach for locally advanced colon cancer with neoadjuvant chemotherapy and surgery[J]. Clin Transl Oncol, 2017, 19(3):379-385.
【17】HUANG C, HUANG MY, MA CJ, et al. Neoadjuvant FOLFOX chemotherapy combined with radiotherapy followed by radical resection in patients with locally advanced colon cancer[J]. Radiat Oncol, 2017, 12(1):48.
【18】SUZUKI C, BLOMQVIST L, SUNDIN A, et al. The initial change in tumor size predicts response and survival in patients with metastatic colorectal cancer treated with combination chemotherapy[J]. Ann Oncol, 2012, 23(4):948-954.
【19】ADAM R, PASCAL G, CASTAING D, et al. Tumor progression while on chemotherapy: a contraindication to liver resection for multiple colorectal metastases?[J]. Ann Surg, 2004, 240(6):1052-1061.
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【21】MODEST DP, LAUBENDER RP, STINTZING S, et al. Early tumor shrinkage in patients with metastatic colorectal cancer receiving first-line treatment with cetuximab combined with either CAPIRI or CAPOX: an analysis of the German AIO KRK 0104 trial[J]. Acta Oncol, 2013, 52(5):956-962.
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【23】ARREDONDO J, MARTINEZ P, BAIXAULI J, et al. Analysis of surgical complications of primary tumor resection after neoadjuvant treatment in stageⅣ colon cancer[J]. J Gastrointest Oncol, 2014, 5(2):148-153.
【24】DEHAL A, GRAFF-BAKER AN, VUONG B, et al. Neoadjuvant chemotherapy improves survival in patients with clinical T4b colon cancer[J]. J Gastrointest Surg, 2018, 22(2):242-249.
【25】LIU F, YANG L, WU Y, et al. CapOX as neoadjuvant chemotherapy for locally advanced operable colon cancer patients: a prospective single-arm phaseⅡ trial[J]. Chin J Cancer Res, 2016, 28(6):589-597.
【26】WIEGERING A, KUNZ M, HUSSEIN M, et al. Diagnostic value of preoperative CT scan to stratify colon cancer for neoadjuvant therapy[J]. Int J Colorectal Dis, 2015, 30(8):1067-1073.
【27】NORGAARD A, DAM C, JAKOBSEN A, et al. Selection of colon cancer patients for neoadjuvant chemotherapy by preoperative CT scan[J]. Scand J Gastroenterol, 2014, 49(2):202-208.
【28】SMITH NJ, BEES N, BARBACHANO Y, et al. Preoperative computed tomography staging of nonmetastatic colon cancer predicts outcome: implications for clinical trials[J]. Br J Cancer, 2007, 96(7):1030-1036.
【29】LEONARS GD, BRENNER B, KEMENY NE. Neoadjuvant chemotherapy before liver resection for patients with unresectable liver metastases from colorectal carcinoma[J]. J Clin Oncol, 2005, 23(9):2038-2048.
【30】VLEDDER MG, DE JONG MC, PAWLIK TM, et al. Disappearing colorectal liver metastases after chemotherapy: should we be concerned?[J]. J Gastrointest Surg, 2010, 14(11):1691-1700.
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