李宗海

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研究经历:
    李宗海,医学博士、研究员,上海交通大学医学院附属仁济医院博士生导师、上海市肿瘤研究所癌基因及相关基因国家重点实验室研究组长、国际药物创新联盟执行理事、美国癌症协会会员、美国基因治疗协会会员、中国医药生物技术协会基因治疗分会首届委员。他长期致力于研制高效安全的抗肿瘤生物药物(主要为抗体药物、靶向给药系统及免疫细胞治疗)和开发肿瘤新治疗靶标。他承担国家新药创制科技重大专项,传染病重大专项,973,国家自然科学基金面上项目,上海市科委重点科技攻关及企业合作项目等十余项课题。在CANCER RESEARCH, BIOMATERIALS, CELL DEATH & DISEASE, FASEB J, JBC, NEOPLASIA, CARCINOGENESIS, CANCER IMMUNOL IMMUNOTHER等国内外学术期刊发表论文六十多篇,参编专著2部,申报发明专利二十余项。获得中国、美国、欧盟授权专利7项。他曾获得教育部新世纪优秀人才、上海市青年科技启明星、上海卫生系统新百人等称号。是国家科技奖励评审专家、国家自然科学基金等多个基金项目评审专家;是十余本国内外学术期刊审稿人。
            

课题组成员:
 
研究人员   电话
蒋华 博士,副研究员,上海交通大学硕士生导师,上海市青年科技启明星 021-64436621
石必枝 副研究员 021-64436621
杨丹波 博士 (人才引进,在交大闵行校区) 021-34207993
梁晓飞 博士(在交大闵行校区) 021-34207993
王华茂 博士 021-64438182
潘晓蓉 博士 021-64436621
周敏 博士 021-64436621
张楫钦 博士 021-64436621
高慧萍 硕士(在职博士生) 021-64436621
孔娟 硕士 021-64436621
张鹏伟 硕士 021-64046619
胡素文 硕士 021-64048388
严瑾 技术员 021-64048388
在读研究生    
徐文 博士 021-64436621
李克桑 博士 021-64048388
范明亮 博士(在交大闵行校区) 021-34207993
陈骋 博士 021-64436621
王彪 博士 021-64436621
董琼娜 硕士 021-64436619
田觅 硕士 021-64436619
马晓 硕士 021-64436619
宋菲 硕士 021-64436621
毕延玉 硕士 021-64436621

研究方向:
肿瘤新靶点及肿瘤生物治疗

主要目标:
★ 抗体为基础的免疫治疗。
★ 受体靶向基因/药物导入系统。
★ 肿瘤新靶点发现与证实

授课:
复旦大学医学院研究生课程《肿瘤分子生物学》,主讲“肿瘤基因治疗”。

  【李宗海】学术著作
代表性论文: 1) Min Zhou, Hai Wang, Keke Zhou, Xiaoying Luo, XiaoRong Pan, Bizhi Shi, Hua Jiang, Jiqin Zhang, Kesang Li, Huamao Wang, Huiping Gao, Shun Lu, Ming Yao, Ying Mao, Hong-Yang Wang, Shengli Yang, Jianren Gu, Chuanyuan Li, and Zonghai Li#. A novel EGFR isoform confers increased invasiveness on cancer cells. Cancer Res. 2013;73(23):7056-7067. 2) Xiaoying Luo, Xiaolan Long, Hailong Xie, Min Zhou , Zhibin Xu, Bizhi Shi, Hua Jiang, Zonghai Li#. EGFRvⅢ mediates hepatocellular carcinoma cell invasion via promoting S100 calcium binding protein A11 expression. PLOS ONE, 2013 Dec 20;8(12):e83332. 3) Pengnan Zhang*, Pengfei Zhang*, Bizhi Shi, Hua Jiang, Haiyan Zhan, Min Zhou, Xiaorong Pan, Huiping Gao, Hong Sun# and Zonghai Li#, Galectin-1 overexpression promotes progression and chemoresistance to cisplatin in epithelial ovarian cancer. Cell Death & Disease, 2014,5:e991. 4) Pengfei Zhang, Bizhi Shi, Huiping Gao, Hua Jiang, Juan Kong, Jin Yan, Xiaorong Pan, Kesang Li, Pengwei Zhang, Ming Yao, Shengli Yang, Jianren Gu, Hongyang Wang, and Zonghai Li#. Elimination of Hepatocellular carcinoma xenograft with limited galactin-1 expression by a EpCAM/CD3 bispecific antibody. Cancer Immunol Immunother. 2014 Feb;63(2):121-132. 5) Hua Jiang*, Qiongna Dong*, Xiaoying Luo, Bizhi Shi, Huamao Wang, Huiping Gao, Juan Kong, Jiqin Zhang, Zonghai Li#. The Monoclonal Antibody CH12 augments 5-fluorouracil-induced Growth Suppression of Hepatocellular Carcinoma Xenografts Expressing Epidermal Growth Factor Receptor Variant III, Cancer Letter, 2014 Jan 1;342(1):113-120. 6) Zhang P, Zhang P, Zhou M, Jiang H, Zhang H, Shi B, Pan X, Gao H, Sun H, Li Z#. Exon 4 deletion variant of epidermal growth factor receptor enhaces invasiveness and cisplatin resistance in epithelial ovarian cancer. Carcinogenesis, 2013 Nov;34(11):2639-2646. 7) Liang X, Li X, Chang J, Duan Y#, Li Z#. Properties and evaluation of quaternized chitosan/lipid cation polymeric liposomes for cancer-targeted gene delivery. Langmuir, 2013;29(27):8683-8693. 8) Yaqiong Yang, Hua Jiang, Huiping Gao, Juan Kong, Pengwei Zhang, Suwen Hu, Bizhi Shi, Pengfei Zhang, Ming Yao, Zonghai Li#. The Monoclonal Antibody CH12 Enhances the Sorafenib-Mediated Growth Inhibition of Hepatocellular Carcinoma Xenografts Expressing Epidermal Growth Factor Receptor Variant III. Neoplasia, 2012;14(6):509-518. 9) Hai Wang, Bizhi Shi, Qingli Zhang, Hua Jiang, Suwen Hu, Juan Kong, Ming Yao, Shengli Yang, Zonghai Li#. Growth and Metastasis Suppression of Glioma Xenografts Expressing Exon 4-deletion Variant of Epidermal Growth Factor Receptor by Monoclonal Antibody CH12–Mediated Receptor Degradation. FASEB J. 2012; 26(1):73-80. 10) Wang JL, Tang GP, Shen J, Hu QL, Xu FJ#, Wang QQ, Li ZH#, Yang WT. A gene nanocomplex conjugated with monoclonal antibodies for targeted therapy of hepatocellular carcinoma. Biomaterials, 2012;33(18):4597-4607. 11) Min Liu*, Zonghai Li*, Fujian Xu,et al. An oligopeptide ligand-mediated therapeutic gene nanocomplex for liver cancer-targeted therapy. Biomaterials, 2012,33(7):2240-2250. (*co-first author) 12) Liang Xiao-Fei#, Hu Jing-Ying, Chen Fu-Hua, Li Zong-Hai#, Chang Jin#. Characterization of Chitosan Polymeric Ethosomes Capable of Encapsulating Hydrophobic and Hydrophilic Drugs Prepared by a Microemulsion Method. Acta Phys. Chim. Sin. 2012;28(4):897-902. 13) Hai Wang, Min Zhou, Bizhi Shi, Qingli Zhang, Hua Jiang, Yinghao Sun, Jianhua Liu, Keke Zhou, Ming Yao, Jianren Gu, Shengli Yang,Ying Mao, Zonghai Li#. Identification of an exon 4-deletion variant of epidermal growth factor receptor with increased metastasis-promoting capacity. Neoplasia, 2011,13(5):461-471. 14) Min Zhou, Jianren Gu, Zonghai Li#. Large-scale production of functional recombinant CAR in a baculovirus-insect cell system. Acta virol. 2011;55(2):93-99. 15) Hua Jiang, Huamao Wang, Zhonghua Tan, Suwen Hu, Hai Wang, Lin Yang, Peiyong Li, Jianren Gu, Hongyang Wang, Zonghai Li#. Growth suppression of human hepatocellular carcinoma xenografts by a monoclonal antibody CH12 directed to epidermal growth factor receptor variant III. J Biol Chem. 2011;286(7):5913-5920. 16) Yicheng Wu, Maoquan Chu#, Bizhi Shi, Zonghai Li#. A Novel Magneto-fluorescent Nano-bioprobe for Cancer Cell Targeting, Imaging and Collection. Appl Biochem Biotechnol. 2011;163(7):813-825. 17) Lin Yang, Hua Jiang, Bizhi Shi, Huamao Wang, Jinjun Li, Hai Wang, Ming Yao, Zonghai Li#. Identification and Characterization of Ch806 Mimotopes. Cancer Immunology Immunotherapy, 2010;59(10):1481-1487. 18) Xiao Yao, Hua Jiang, Cuizhen Zhang, Huamao Wang, Lin Yang, Yongfeng Yu, Bizhi Shi, Zhiwei chen, Shujun Tian, Shun Lu#, Zonghai Li#,Jianren Gu. Dikkopf-1 autoantibody is a novel serologic biomarker for non–small cell lung cancer (NSCLC). Biomarkers, 2010;15(2):128-134. 19) Min Zhou, Bangdong Gong, Jianren Gu, Zonghai Li. EGFRvIII mRNA detection in the serum of patients with hepatocellular carcinoma. Liver Int. 2010;30(6):925-927. 20) Huamao Wang, Hua Jiang, Min Zhou, Zhibing Xu, Shiguo Liu, Bizhi Shi, Xiao Yao, Ming Yao, JianRen Gu, Zonghai Li#. Epidermal Growth Factor Receptor vIII enhances tumorigenicity and resistance to 5-Fluorouracil in Human Hepatocellular Carcinoma. Cancer letters, 2009;279(1):30-38. 21) Jiang Hua, Xiumei Cai, Bizhi Shi,Jie Zhang, Zonghai Li#, Jianren Gu.Development of efficient RNA interference system using EGF-displaying phagemid particles. Acta Pharmacol Sin. 2008;29(4):437-442. 22) Bizhi Shi, Huamao Wang, Shengrong Guo, Yuhong Xu, Zonghai Li#, Jianren Gu#. Protein III-based single-chain antibody phage display using bacterial cells bearing an additional genome of a gene-III-lacking helper phage. BioTechniques, 2007;42(6):756-759. 23) Hua Jiang, Jie Zhang, Bizhi Shi, Yuhong Xu, Zonghai Li#, Jianren Gu #.Application of EGFP-EGF Fusions to Explore the Mechanism of Endocytosis of Epidermal Growth Factor Receptor. Acta Pharmacol Sin. 2007;28(1):111-117. 24) Zonghai Li#, Hua Jiang, Jie Zhang, Jianren Gu.Cell targeted phagemid particles preparation using E.coli bearing ligand-pIII encoding helper phage genome. BioTechniques, 2006;41(6):706-707. 25) Yun Liang, Bizhi Shi, Jie Zhang, Hua Jiang, Yuhong Xu, Zonghai Li#,Jianren Gu#. Better Gene Expression by (-)Gene than by (+) Gene in phage gene delivery systems. Biotechnology Progress, 2006;22(3):626-630. 26) Zonghai Li, Ruijiao Zhao, Xianghua Wu, Ye Sun, Ming Yao, Jinjun Li, Yuhong Xu#, Jianren Gu#. Identification and characterization of a novel peptide ligand of epidermal growth factor receptor for targeted delivery of therapeutics. FASEB J, 2005;19(14):1978-1985. 27) Zonghai Li, Jie Zhang, Ruijiao Zhao, Yuhong Xu#, Jianren Gu#. Preparation of peptide-targeted phagemid particles using protein III modified helper phage. BioTechniques, 2005;39(4): 493-496. Note: # Corresponding author 编著: 1、参编《抗肿瘤药物研究与开发》 甄永苏 主编,化工出版社,2004 第一版 2、《当代药理学》第二版,刘耕陶主编,中国协和医科大学出版社出版,2008年5月, 第二版

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