8q24 rs13281615单核苷酸多态性与乳腺癌发病风险的Meta分析
Association between a single nucleotide polymorphism in 8q24 rs13281615 and breast cancer risk: a Meta-analysis
摘 要
目的:探讨8q24 rs13281615单核苷酸多态性(singl enucleotide polymorphism,SNP)与乳腺癌发病风险的关系。方法:检索PubMed、Medline、Embase、中国知网(China National Knowledge Infrastructure,CNKI)和万方数字化期刊等中英文数据库。以乳腺癌病例组和对照组人群基因型分布计算粗比值比(oddsratios,OR)和95%可信区间(95% confidence interval,CI),采用RevMan 5.1软件进行Meta分析和文献偏倚的评估。结果:共纳入7篇研究文献,累积病例22128例,累积对照29276例。采用随机效应模型,与野生纯合子(AA)相比,携带杂合子(AG)和突变纯合子(GG)的妇女发生乳腺癌的合并风险上升(OR=1.14,95%CI:1.04~1.25),尤其是欧洲妇女乳腺癌的发病风险增加(OR=1.14,95%CI:1.02~1.28)。结论:8q24 rs13281615的G等位基因型可能会增加乳腺癌的发病风险。
多态现象
单核苷酸
Meta分析
8q24 rs
Breast neoplasms
Polymorphism
single nucleotide
Meta-analysis
8q24 rs
Abstract
Objective: To investigate the association between the single nucleotide polymorphism(SNP) in 8q24 rsl3281615 and breast cancer risk. Methods: The studies were identified by searching Chinese and English databases including PubMed, Medline, Embase, China National Knowledge Infrastructure(CNKI) and WanFang Data. The crude odds ratio(OR) and 95% confidence interval(CI) were calculated by the distribution of genotypes in the patients with breast cancer and the controls. The Meta analysis was conducted and the bias in studies was evaluated by RevMan 5.1 software. Results: A total of 7 casecontrol studies were eligible for this study, including 22128 cumulative cases of breast cancer and 29276 controls. The combined risk was higher in the carriers with heterozygous(AG) and homozygous(GG) genotypes than that in the carriers with wild genotype(AA)(OR=1.14, 95% CI:1.04-1.25) by using random effects model. This effect was especially significant in European women(OR=1.14, 95% CI:1.02-1.28). Conclusion: The G allele of 8q24 rs13281615 may increase the risk of breast cancer.
中图分类号 R737.9 DOI 10.3781/j.issn.1000-7431.2012.01.007
所属栏目 流行病学研究
基金项目 国家自然科学基金资助项目(编号:30872172);天津市科技计划资助项目(编号:09ZCZDSF04700)
收稿日期 2011/7/21
修改稿日期 2011/9/15
网络出版日期
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引用该论文: SONG Jun-ying,ZHANG Li-na,ZHENG Hong,CHEN Ke-xin. Association between a single nucleotide polymorphism in 8q24 rs13281615 and breast cancer risk: a Meta-analysis[J]. Tumor, 2012, 32(1): 38～41
宋俊颖,张丽娜,郑红,陈可欣. 8q24 rs13281615单核苷酸多态性与乳腺癌发病风险的Meta分析[J]. 肿瘤, 2012, 32(1): 38～41
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参考文献
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【19】李莉华, 郭子健, 华 东, 等. 8q24 rsl3281615 基因多态性与中国汉族女性乳腺癌患病风险及临床病理特征的关系[J].中华检验医学杂志, 2011, 34(1):73-76.
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【21】MEYER A, SCHURMANN P, GHAHREMANI M, et al.Association of chromosomal locus 8q24 and risk of prostate cancer:a hospital-based study ofGerman patients treated with brachytherapy[J].Urol Oncol, 2009, 27(4):373-376.
【2】STURGEON S R, SCHAIRER C, GRAUMAN D,et al. Trends in breast cancer mortality rates byregion of the United States, 1950-1999[J]. CancerCauses Control, 2004, 15(10):987-995.
【3】KENNEDY G C, MATSUZAKI H, DONG S, et al.Large-scale genotyping of complex DNA[J]. NatBiotechnol, 2003, 21(10):1233-1237.
【4】PURCELL S, NEALE B, TODD-BROWN K, et al.PLINK:a tool set for whole-genome association and population-based linkage analyses[J]. Am JHum Genet, 2007, 81(3):559-575.
【5】CANTOR R M, LANGE K, SINSHEIMER J S.Prioritizing GWAS results:A review of statistical methods and recommendations for their application[J]. Am J Hum Genet, 2010, 86(1):6-22.
【6】STEEMERS F J, GUNDERSON K L. Whole genomegenotyping technologies on the Bead Array platform[J]. Biotechnol J, 2007, 2(1):41-49.
【7】江军仪, 项永兵, 陶梦华, 等. 乳腺癌基因环境交互作用的研究进展[J].肿瘤, 2011, 31(6):558-564.
【8】EASTON D F, POOLEY K A, DUNNING A M, et al.Genome-wide association study identifies novelbreast cancer susceptibility loci[J]. Nature, 2007,447(7148):1087-1093.
【9】TOMLINSON I, WEBB E, CARVAJAL-CARMONA L,et al. A genome-wide association scan of tagSNPs identifies a susceptibility variant forcolorectal cancer at 8q24.21[J]. Nat Genet, 2007,39(8):984-988.
【10】FLETCHER O, JOHNSON N, GIBSON L, et al.Association of genetic variants at 8q24 with breast cancer risk[J]. Cancer Epidemiol Biomarkers Prev, 2008, 17(3):702-705.
【11】ZHENG W, WEN W, GAO Y T, et al. Genetic and clinical predictors for breast cancer risk assessment and stratification amongChinese women[J]. J Natl Cancer Inst, 2010,102(13):972-981.
【12】HIGGINS J P, THOMPSON S G, DEEKS J J, et al.Measuring inconsistency in meta-analyses[J]. BMJ,2003, 327(7414):557-560.
【13】STROUP D F, BERLIN J A, MORTON S C, et al. Meta analysis of observational studies in epidemiology:a proposal for reporting. Meta-analysis OfObservational Studies in Epidemiology (MOOSE)group[J]. JAMA, 2000, 283(15):2008-2012.
【14】GARCIA-CLOSAS M, HALL P, NEVANLINNA H, et al.Heterogeneity of breast cancer associations withfive susceptibility loci by clinical and pathological characteristics[J]. PLoS Genet, 2008, 4(4):e1000054.
【15】MCINERNEY N, COLLERAN G, ROWAN A, et al. Lowpenetrance breast cancer predisposition SNPs aresite specific[J]. Breast Cancer Res Treat, 2009,117(1):151-159.
【16】TAMIMI R M, LAGIOU P, CZENE K, et al. Birthweight, breast cancer susceptibility loci, and breast cancer risk[J]. Cancer Causes Control,2010, 21(5):689-696.
【17】LONG J, SHU X O, CAI Q, et al. Evaluation of breast cancer susceptibility loci in Chinese women[J].Cancer Epidemiol Biomarkers Prev, 2010,19(9):2357-2365.
【18】JIANG Y, HAN J, LIU J, et al. Risk of genomewideassociation study newly identified geneticvariants for breast cancer in Chinese women of Heilongjiang Province[J]. Breast Cancer Res Treat,2011, 128(1):251-257.
【19】李莉华, 郭子健, 华 东, 等. 8q24 rsl3281615 基因多态性与中国汉族女性乳腺癌患病风险及临床病理特征的关系[J].中华检验医学杂志, 2011, 34(1):73-76.
【20】ZIV E, JOHN E M, CHOUDHRY S, et al. Geneticancestry and risk factors for breast canceramong Latinas in the San Francisco Bay Area[J].Cancer Epidemiol Biomarkers Prev, 2006,15(10):1878-1885.
【21】MEYER A, SCHURMANN P, GHAHREMANI M, et al.Association of chromosomal locus 8q24 and risk of prostate cancer:a hospital-based study ofGerman patients treated with brachytherapy[J].Urol Oncol, 2009, 27(4):373-376.
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