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EPHX 1基因多态性与原发性肝癌易感性的关系
         
Polymorphism of microsomal epoxidehydrolase and susceptibility to primary hepatocellular carcinoma

摘    要
目的:探讨Ⅱ相代谢酶微粒体环氧化物水解酶EPHX1基因多态性和烟酒习惯及其相互作用与原发性肝癌易感性的关系.方法:采用病例-对照研究和聚合酶链式反应-限制性片段长度多态性(polymerase chain reaction-restriction fragment length polymorphism,PCR-RFLP)技术对广西地区105例原发性肝癌患者及151例健康对照者的EPHX1第3外显子113密码子基因型进行检测,并调查研究对象的烟酒习惯.结果:EPHX1第3外显子113密码子Tyr/Tyr、Tyr/His、His/His3种基因型频率在病例组分别为27.62%、21.90%、50.48%,对照组则分别为21.19%、34.44%、44.37%,2组差异无统计学意义(P > 0.05);EPHX1第3外显子113密码子基因型为His/His的个体在吸烟因素存在时,发生肝癌的危险性增加,OR值为2.99(95%CI:1.29~6.91);在HBV阳性的人群中,吸烟和饮酒习惯与EPHX1易感基因型对肝癌的发生有明显的协同作用.结论:EPHX1第3外显子基因多态与吸烟、饮酒等环境因素的相互作用可能增加个体患肝癌的危险性.
标    签 肝肿瘤   多态现象,遗传   生活方式   微粒体环氧化物水解酶   Liver neoplasms   Polymorphism, genetic   Life style   Microsomal epoxide hydrolase  
 
Abstract
Objective: This study intended to explore there lationships of the polymorphism of phase Ⅱ drug-metabo lizingen-zyme, microsomal epoxide hydrolase 1 (EPHX1) with the habits of smoking and alcohol drinking, and their in teractions on risk of developing prmiary hepato cellular carcinoma(HCC).Methods: The genotypes at codon 113 of exon 3 of gene EPHX1 were analyzed in 105 patients with HCC and 151 healthy controls in Guangxi Province by using polymerase chain reaction followed by restriction fragment length polymorphism(PCR-RFLP).The habits of smoking and alcohol drinking of all the subjects were investigated. Results: The frequencies of Tyr/Tyr, Tyr/H is and His/His genotypes at codon 113 of exon 3 of gene EPHX1 were 27.62%, 21.90%, and 50.48% for HCC patients and 21.19%, 34.44%, and 44.37% for healthy controls, respectively. There was no significant difference (P > 0.05).Smoking increased the risk of developing HCC for patients with His/His genotype. The ORvalue was 2.99 (95%CI:1.29-6.91).For the HBV-positive patients, polymorphism of EPHX 1 and the habits of smoking and alcohol drinking had synergistic effects on the development of HCC.Conclusion: The interaction between the environmental factors such as smoking and alcohol drinking and polymorphism of EPHX1 gene may increase the risk of developing HCC.

中图分类号 R735.7 R730.231   DOI 10.3781/.jissn.1000-7431.2008.02.008

 
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所属栏目 流行病学研究

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收稿日期 2007/7/3

修改稿日期 2007/10/15

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备注贺菽嘉(1976-),女(汉族),博士研究生,讲师

引用该论文: HE Shu-jia,GU Yong-yao,LIN Wen-zhen,ZENG Xiao-yun,LIAO Zhi-hong. Polymorphism of microsomal epoxidehydrolase and susceptibility to primary hepatocellular carcinoma[J]. Tumor, 2008, 28(2): 125~128
贺菽嘉,顾永耀,林文珍,曾小云,廖志红. EPHX 1基因多态性与原发性肝癌易感性的关系[J]. 肿瘤, 2008, 28(2): 125~128


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参考文献
【1】SPURDLE A B,CHANG J H,BYRNES G B,et al. A systematic approach to analysing gene-gene interactions:polymorphisms at the microsomal epoxide hydrolase EPHX and glutathione S-transferase GSTM1,GSTT1,and GSTP1 loci and breast cancer risk[J].Cancer Epidemiology Biomarkers and Prevention,2007,16(04):769-774.
 
【2】VOHO A,METSOLA K,ANTTILA S,et al. EPHX 1 gene polymorphisms and individual susceptibility to lung cancer[J].Cancer Letters,2006,237(01):102-108.
 
【3】KIRK G D,TUMER P C,GONG Y,et al. Hepatocellular carcinoma and polymorphisms in carcinogen-metabolizing and DNA repair enzyme in a population with aflatoxin exposure and hepatitis B virus endemicity[J].Cancer Epidemiology Biomarkers and Prevention,2005,14(02):373-379.
 
【4】XIAO D,WANG C,DU M J,et al. Relationship between polymorphisms of genes encoding microsomal epoxide hydrolases and glutathione S-tranferase P1 and chronic obstructive pulmonary di-sease[J].Chinese Medical Journal,2004,117(05):661-667.
 
【5】曹燕燕,边建超,江峰,等. 环氧化物水解酶基因多态与肝癌的遗传易感性[J].复旦学报(医学版),2004,31(04):363-367.
 
【6】贺菽嘉,覃甲仁,顾永耀,等. Ⅱ相代谢酶基因多态性与广西肝癌发生的关系[J].实用癌症杂志,2004,19(05):460-462.
 
【7】JEE S H,OHRR H,SULL J W,et al. Cigarette smoking,alcohol driking,hepatitis B,and risk for hepatocellular carcinoma in Korea[J].Journal of the National Cancer Institute,2004,96(24):1851-1856.
 
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