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IL-4R在非小细胞肺癌中的表达及其临床意义
          
Expression of interleukin-4 receptor in non-small cell lung cancer and its clinical significance

摘    要
目的:探讨白细胞介素-4受体(interleukin-4 receptor,IL-4R)在非小细胞肺癌(non-small cell lung cancer,NSCLC)患者手术前后外周血中的表达及其临床意义。
方法:应用实时荧光定量PCR和ELISA法检测84例NSCLC患者手术前后及40例健康志愿者外周血中IL-4R的表达水平,应用免疫组织化学法检测NSCLC癌组织及其相应癌旁组织中IL-4R的表达,分析IL-4R的表达与患者临床病理因素及预后的关系。
结果:NSCLC患者手术前后外周血中IL-4R的表达水平高于健康志愿者,而NSCLC患者手术后IL-4R的表达水平低于手术前,但仍高于健康志愿者,差异均有统计学意义(P值均 < 0.05)。NSCLC组织中IL-4R的阳性表达率高于相应的癌旁组织(P < 0.05)。手术后外周血IL-4R mRNA高表达的NSCLC患者的总生存时间(overoverall survival,OS)和无病生存时间(disease free survival,DFS)短于IL-4R mRNA低表达者(P值均 < 0.001)。肿瘤分期、复发、转移和IL-4R mRNA的表达水平是NSCLC患者的独立预后因素(P值均 < 0.05)。
结论:NSCLC患者外周血中IL-4R高表达,IL-4R的表达水平是NSCLC患者的独立预后因素之一。
标    签 癌,非小细胞肺   基因表达   预后   白细胞介素-4受体   Carcinoma, non-small cell lung   Gene expression   Prognosis   Interleukin-4 receptor  
 
Abstract
Objective: To investigate the expression of interleukin-4 receptor (IL-4R) in peripheral blood of patients with non-small cell lung cancer (NSCLC) before and after surgical operation and its clinical significance.
Methods: The expression levels of IL-4R in peripheral blood of 84 patients with NSCLC before and after surgical operation as well as in peripheral blood of 40 healthy volunteers were measured by real-time fluorescent quantitative-PCR and ELISA. The expressions of IL-4R in NSCLC tissues and the corresponding para-cancerous tissues were detected by immunohistochemistry. The correlations of IL-4R expression with clinicopathological characteristics and prognosis were analyzed.
Results: The expression levels of IL-4R in peripheral blood of patients with NSCLC before and after surgical operation were both higher than that of healthy volunteers. The expression level of IL-4R in peripheral blood of patients with NSCLC after surgical operation was lower as compared with that before surgical operation, but which was higher than that of healthy volunteers (all P < 0.05). The positive expression rate of IL-4R in NSCLC tissues was higher than that in the corresponding para-cancerous tissues (P < 0.05). The overall survival and disease-free survival of NSCLC patients with high expression of IL-4R mRNA were poorer than those of the patients with low expression of IL-4R mRNA (both P < 0.001). Tumor stage, recurrence, metastasis and IL-4R mRNA level were independent prognostic factors of NSCLC (all P < 0.05).
Conclusion: IL-4R in peripheral blood of patients with NSCLC is up-regulated, and the expression level of IL-4R is one of the independent prognostic factors of NSCLC.

中图分类号 R734.2   DOI 10.3781/j.issn.1000-7431.2015.33.503

 
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所属栏目 临床研究

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收稿日期 2015/6/23

修改稿日期 2015/7/23

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引用该论文: ZHENG Zhigang,HE Pengfei,HAN Jun,LIAO Jihong. Expression of interleukin-4 receptor in non-small cell lung cancer and its clinical significance[J]. Tumor, 2015, 35(10): 1144~1152
郑志刚,何鹏飞,韩军,廖继红. IL-4R在非小细胞肺癌中的表达及其临床意义[J]. 肿瘤, 2015, 35(10): 1144~1152


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