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乳腺癌组织中CAP1的表达及其临床意义
         
Expression of cyclase-associated protein 1 in breast cancer tissues and its clinical significance

摘    要
目的:探讨环化酶相关蛋白1(cyclase-associated protein 1,CAP1)在乳腺癌组织中的表达及其临床意义。方法:收集93例乳腺癌组织及其相应的癌旁组织,应用免疫组织化学法检测CAP1和增殖抗原Ki-67在乳腺癌组织及其相应癌旁组织中的表达,分析CAP1与乳腺癌患者临床病理参数之间的关系以及对乳腺癌患者预后的影响。结果:乳腺癌组织中CAP1和Ki-67的表达水平均高于其相应的癌旁组织(P值均<0.01)。CAP1和Ki-67高表达与乳腺癌组织的分化程度(P<0.001和P=0.001)、腋窝淋巴结转移(P=0.011和P=0.007)和雌激素受体(estrogen receptor,ER)表达(P=0.031和P=0.026)有关,但与患者的年龄、肿瘤大小、组织学类型、孕激素受体(progesterone receptor,PR)表达、人类表皮生长因子受体2(human epidermal growth factor receptor-2,HER2)表达和p53表达无关(P值均>0.05);乳腺癌组织中CAP1表达与Ki-67表达呈正相关(r2=0.403,P=0.002)。组织分化程度、腋窝淋巴结状态、CAP1表达和Ki-67表达是乳腺癌患者预后的独立影响因素(P值均<0.05)。结论:乳腺癌组织中CAP1高表达,可能在乳腺癌细胞增殖中发挥重要作用。
标    签 乳腺肿瘤   基因表达   预后   环化酶相关蛋白1   Breast neoplasms   Gene expression   Prognosis   Cyclase-associated protein 1  
 
Abstract
Objective:To investigate the expression of cyclase-associated protein 1 (CAP1) in breast cancer tissues and its clinical significance. Methods:Overall 93 specimens of breast cancer tissues and the para-cancerous tissues were collected. The expressions of CAP1 and Ki-67 in breast cancer tissues and the para-cancerous tissues were detected by immunohistochemistry. The correlations of CAP1 with clinicopathological features and the prognosis were analyzed. Results:The expression levels of CAP1 and Ki-67 in breast cancer tissues were higher than those in the para-cancerous tissues (both P<0.01). The high expressions of CAP1 and Ki-67 were associated with differentiation (P<0.001, P=0.001), axillary lymph node metastasis (P=0.011, P=0.007) and estrogen receptor (ER) expression (P=0.031, P=0.026), whereas they were not associated with age, tumor size, histologic type and the expressions of progesterone receptor (PR), human epidermal growth factor receptor-2 (HER2) and p53 (all P>0.05). There was a positive correlation between CAP1 expression and Ki-67 in breast cancer tissues (r2=0.403, P=0.002). The differentiation, axillary lymph node status, CAP1 expression and Ki-67 were independent prognostic factors of breast cancer (all P<0.05). Conclusion:The expression of CAP1 is high in breast cancer tissues. CAP1 may play an important role in proliferation in breast cancer cells.

中图分类号 R737.9   DOI 10.3781/j.issn.1000-7431.2016.33.493

 
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所属栏目 临床研究

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收稿日期 2016/7/28

修改稿日期 2016/9/29

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引用该论文: CHENG Haiyan,CUI Hengfeng,SHI Yuhua. Expression of cyclase-associated protein 1 in breast cancer tissues and its clinical significance[J]. Tumor, 2016, 36(11): 1233~1238
程海燕,崔恒锋,施育华. 乳腺癌组织中CAP1的表达及其临床意义[J]. 肿瘤, 2016, 36(11): 1233~1238


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参考文献
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【3】Zhang H, Ghai P, Wu H, et al. Mammalian adenylyl cyclaseassociated protein 1(CAP1) regulates cofilin function, the actin cytoskeleton, and cell adhesion[J]. J Biol Chem, 2013, 288(29):20966-20977.
 
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