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叉头框Q1基因调控肿瘤发生和发展的研究进展
         
Progress in research on regulation of tumor occurrence and development by forkhead box Q1 gene

摘    要
转录因子叉头框Q1(forkhead box Q1,FOXQ1)是叉头框超家族的成员之一,参与多种生物学过程,并在肿瘤的发生和发展中发挥重要作用。FOXQ1蛋白通过直接作用于靶基因的启动子或与其他转录因子相互作用间接激活靶基因的转录,并通过促进上皮-间质转化(epithelial-mesenchymal transition,EMT)和激活多条细胞信号转导通路而影响肿瘤的发生、发展、侵袭和转移。研究表明,FOXQ1基因与多种肿瘤的发生和发展显著相关,FOXQ1基因的表达水平可作为判断多种肿瘤预后的指标。本文主要综述FOXQ1基因在肿瘤发生和发展中可能的作用机制。
标    签 肿瘤   信号转导   上皮-间质转化   FOXQ1基因   Neoplasms   Signal transduction   Epithelial-mesenchymal transition   FOXQ1 gene  
 
Abstract
The transcription factor forkhead box Q1 (FOXQ1), a member of the forkhead box superfamily, is involved in various biological processes, and it also plays an important role in tumorigenesis and development. FOXQ1 protein activates the transcription by directly binding to the promoter of target genes or indirectly interacting with other transcription factors, and it affects initiation, progression, invasion and metastasis of tumor by promoting epithelial-mesenchymal transition (EMT) and activating multiple cellular signal transduction pathways. Previous studies have indicated that FOXQ1 gene is significantly associated with the occurrence and development of a variety of tumors. The expression level of FOXQ1 gene can be used as a prognostic indicator to judge the prognosis of various tumors. This review focuses on the possible mechanism of FOXQ1 gene in tumorigenesis and development.

中图分类号 R730.23   DOI 10.3781/j.issn.1000-7431.2017.55.641

 
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基金项目 国家自然科学基金资助项目(编号:81502556,81260323);云南省中青年学术技术带头人后备人才培养基金(编号:2013HB083)

收稿日期 2016/10/10

修改稿日期 2016/11/30

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引用该论文: ZHANG Jinjin,TANG Hui. Progress in research on regulation of tumor occurrence and development by forkhead box Q1 gene[J]. Tumor, 2017, 37(2): 177~183
张锦锦,唐慧. 叉头框Q1基因调控肿瘤发生和发展的研究进展[J]. 肿瘤, 2017, 37(2): 177~183


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