叉头框Q1基因调控肿瘤发生和发展的研究进展
Progress in research on regulation of tumor occurrence and development by forkhead box Q1 gene
摘 要
转录因子叉头框Q1（forkhead box Q1，FOXQ1）是叉头框超家族的成员之一，参与多种生物学过程，并在肿瘤的发生和发展中发挥重要作用。FOXQ1蛋白通过直接作用于靶基因的启动子或与其他转录因子相互作用间接激活靶基因的转录，并通过促进上皮-间质转化（epithelial-mesenchymal transition，EMT）和激活多条细胞信号转导通路而影响肿瘤的发生、发展、侵袭和转移。研究表明，FOXQ1基因与多种肿瘤的发生和发展显著相关，FOXQ1基因的表达水平可作为判断多种肿瘤预后的指标。本文主要综述FOXQ1基因在肿瘤发生和发展中可能的作用机制。
信号转导
上皮-间质转化
FOXQ1基因
Neoplasms
Signal transduction
Epithelial-mesenchymal transition
FOXQ1 gene
Abstract
The transcription factor forkhead box Q1 (FOXQ1), a member of the forkhead box superfamily, is involved in various biological processes, and it also plays an important role in tumorigenesis and development. FOXQ1 protein activates the transcription by directly binding to the promoter of target genes or indirectly interacting with other transcription factors, and it affects initiation, progression, invasion and metastasis of tumor by promoting epithelial-mesenchymal transition (EMT) and activating multiple cellular signal transduction pathways. Previous studies have indicated that FOXQ1 gene is significantly associated with the occurrence and development of a variety of tumors. The expression level of FOXQ1 gene can be used as a prognostic indicator to judge the prognosis of various tumors. This review focuses on the possible mechanism of FOXQ1 gene in tumorigenesis and development.
中图分类号 R730.23 DOI 10.3781/j.issn.1000-7431.2017.55.641
所属栏目 综述
基金项目 国家自然科学基金资助项目（编号：81502556，81260323）；云南省中青年学术技术带头人后备人才培养基金（编号：2013HB083）
收稿日期 2016/10/10
修改稿日期 2016/11/30
网络出版日期
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引用该论文: ZHANG Jinjin,TANG Hui. Progress in research on regulation of tumor occurrence and development by forkhead box Q1 gene[J]. Tumor, 2017, 37(2): 177～183
张锦锦,唐慧. 叉头框Q1基因调控肿瘤发生和发展的研究进展[J]. 肿瘤, 2017, 37(2): 177～183
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参考文献
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【2】吴红雁, 范方田, 刘兆国, 等. 转录因子叉头框Q1与肿瘤相关性的研究进展[J]. 肿瘤, 2014, 34(7):662-667.
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【6】Jackson BC, Carpenter C, Nebert DW, et al. Update of human and mouse forkhead box (FOX) gene families[J]. Human Genomics, 2010, 4(5):345-352.
【7】Lai E, Prezioso VR, Smith E, et al. HNF-3A, a hepatocyte-enriched transcription factor of novel structure is regulated transcriptionally[J]. Genes Dev, 1990, 4(8):1427-1436.
【8】Bieller A, Pasche B, Frank S, et al. Isolation and characterization of the human forkhead gene FOXQ1[J]. DNA Cell Biol, 2001, 20(9):555-561.
【9】Kaneda H, Arao T, Tanaka K, et al. FOXQ1 is overexpressed in colorectal cancer and enhances tumorigenicity and tumor growth[J]. Cancer Res, 2010, 70(5):2053-2063.
【10】Zhang J, Liu Y, Cui X, et al. FOXQ1 promotes gastric cancer metastasis through upregulation of Snail[J]. Oncol Rep, 2016, 35(6):3607-3613.
【11】Xiao B, Liu H, Gu Z, et al. Expression of microRNA-133 inhibits epithelial-mesenchymal transition in lung cancer cells by directly targeting FOXQ1[J]. Arch Bronconeumol, 2016, 52(10):505-511.
【12】Gao M, Shih IeM, Wang TL. The role of forkhead box Q1 transcription factor in ovarian epithelial carcinomas[J]. Int J Mol Sci, 2012, 13(11):13881-13893.
【13】Meng F, Speyer CL, Zhang B, et al. PDGFRalpha and beta play critical roles in mediating Foxq1-driven breast cancer stemness and chemoresistance[J]. Cancer Res, 2015, 75(3):584-593.
【14】Zhang M, Xu Q, Yan S, et al. Suppression of forkhead box Q1 by microRNA-506 represses the proliferation and epithelial-mesenchymal transition of cervical cancer cells[J]. Oncol Rep, 2016, 35(5):3106-3114.
【15】Zhang J, Yang Y, Yang T, et al. Double-negative feedback loop between microRNA-422a and forkhead box (FOX)G1/Q1/E1 regulates hepatocellular carcinoma tumor growth and metastasis[J]. Hepatology, 2015, 61(2):561-573.
【16】Sun HT, Cheng SX, Tu Y, et al. FoxQ1 promotes glioma cells proliferation and migration by regulating NRXN3 expression[J]. PLoS One, 2013, 8(1):e55693.
【17】Vishnubalaji R, Hamam R, Yue S, et al. MicroRNA-320 suppresses colorectal cancer by targeting SOX4, FOXM1, and FOXQ1[J]. Oncotarget, 2016, 7(24):35789-35802.
【18】Christensen J, Bentz S, Sengstag T, et al. FOXQ1, a novel target of the Wnt pathway and a new marker for activation of wnt signaling in solid tumors[J]. PLoS One, 2013, 8(3):e60051.
【19】Peng X, Luo Z, Kang Q, et al. FOXQ1 mediates the crosstalk between TGF-beta and Wnt signaling pathways in the progression of colorectal cancer[J]. Cancer Biol Ther, 2015, 16(7):1099-1109.
【20】Xia L, Huang W, Tian D, et al. Forkhead box Q1 promotes hepatocellular carcinoma metastasis by transactivating ZEB2 and VersicanV1 expression[J]. Hepatology, 2014, 59(3):958-973.
【21】Bao B, Azmi AS, Sarkar FH. Pancreatic cancer stem-like cells display aggressive behavior mediated via activation of FoxQ1[J]. J Biol Chem, 2014, 289(21):14520-14533.
【22】Liang SH,Yan XZ,Wang BL,et al. Increased expression of FOXQ1 is a prognostic marker for patients with gastric cancer[J].Tumour Biol, 2013, 34(5):2605-2609.
【23】Xiang XJ, Deng J, Liu YW, et al. MiR-1271 inhibits cell proliferation, invasion and EMT in gastric cancer by targeting FOXQ1[J]. Cell Physiol Biochem, 2015, 36(4):1382-1394.
【24】Feng J, Zhang XS, Zhu HJ, et al. FoxQ1 overexpression influences poor prognosis in non-small cell lung cancer, associates with the phenomenon of EMT[J/OL]. PLoS One, 2012, 7(6):e39937.
【25】Feng J, Xu L, Ni S, et al. Involvement of FoxQ1 in NSCLC through regulating EMT and increasing chemosensitivity[J]. Oncotarget, 2014, 5(20):9689-9702.
【26】张甦, 邢建明, 钱净. 宫颈癌中Foxq1与NF-κBp65的表达及临床病理意义[J]. 第二军医大学学报, 2009, 30(3):300-304.
【27】Wang W, He S, Ji J, et al. The prognostic significance of FOXQ1 oncogene overexpression in human hepatocellular carcinoma[J]. Pathol Res Pract, 2013, 209(6):353-358.
【28】Huang W, Chen Z, Shang X, et al. Promotes hepatocellular carcinoma metastasis through up-regulating Twist1 and FGFBP1[J]. Hepatology, 2015, 61(2):1920-1933.
【29】Zhang H, Meng F, Liu G, et al. Forkhead transcription factor foxq1 promotes epithelial-mesenchymal transition and breast cancer metastasis[J]. Cancer Res, 2011, 71(4):1292-1301.
【30】Sehrawat A, Kim SH, Vogt A, et al. Suppression of FOXQ1 in benzyl isothiocyanate-mediated inhibition of epithelial-mesenchymal transition in human breast cancer cells[J]. Carcinogenesis, 2013, 34(4):864-873.
【31】Ross JB, Huh D, Noble LB, et al. Identification of molecular determinants of primary and metastatic tumour re-initiation in breast cancer[J]. Nat Cell Biol, 2015, 17(5):651-664.
【32】Kim SH, Kaschula CH, Priedigkeit N, et al. Forkhead box Q1 is a novel target of breast cancer stem cell inhibition by diallyl trisulfide[J]. J Biol Chem, 2016, 291(26):13495-13508.
【2】吴红雁, 范方田, 刘兆国, 等. 转录因子叉头框Q1与肿瘤相关性的研究进展[J]. 肿瘤, 2014, 34(7):662-667.
【3】Kaufmann E, Kniichel W. Five years on the wings of fork head[J]. Mech Dev, 1996, 57(1):3-20.
【4】Myatt SS, Lam EW. The emerging roles of forkhead box (Fox) proteins in cancer[J]. Nat Rev Cancer, 2007, 7(11):847-859.
【5】Kaestner KH, Knochel W, Martinez DE. Unified nomenclature for the winged helix/forkhead transcription factors[J]. Genes Dev, 2000, 14(2):142-146.
【6】Jackson BC, Carpenter C, Nebert DW, et al. Update of human and mouse forkhead box (FOX) gene families[J]. Human Genomics, 2010, 4(5):345-352.
【7】Lai E, Prezioso VR, Smith E, et al. HNF-3A, a hepatocyte-enriched transcription factor of novel structure is regulated transcriptionally[J]. Genes Dev, 1990, 4(8):1427-1436.
【8】Bieller A, Pasche B, Frank S, et al. Isolation and characterization of the human forkhead gene FOXQ1[J]. DNA Cell Biol, 2001, 20(9):555-561.
【9】Kaneda H, Arao T, Tanaka K, et al. FOXQ1 is overexpressed in colorectal cancer and enhances tumorigenicity and tumor growth[J]. Cancer Res, 2010, 70(5):2053-2063.
【10】Zhang J, Liu Y, Cui X, et al. FOXQ1 promotes gastric cancer metastasis through upregulation of Snail[J]. Oncol Rep, 2016, 35(6):3607-3613.
【11】Xiao B, Liu H, Gu Z, et al. Expression of microRNA-133 inhibits epithelial-mesenchymal transition in lung cancer cells by directly targeting FOXQ1[J]. Arch Bronconeumol, 2016, 52(10):505-511.
【12】Gao M, Shih IeM, Wang TL. The role of forkhead box Q1 transcription factor in ovarian epithelial carcinomas[J]. Int J Mol Sci, 2012, 13(11):13881-13893.
【13】Meng F, Speyer CL, Zhang B, et al. PDGFRalpha and beta play critical roles in mediating Foxq1-driven breast cancer stemness and chemoresistance[J]. Cancer Res, 2015, 75(3):584-593.
【14】Zhang M, Xu Q, Yan S, et al. Suppression of forkhead box Q1 by microRNA-506 represses the proliferation and epithelial-mesenchymal transition of cervical cancer cells[J]. Oncol Rep, 2016, 35(5):3106-3114.
【15】Zhang J, Yang Y, Yang T, et al. Double-negative feedback loop between microRNA-422a and forkhead box (FOX)G1/Q1/E1 regulates hepatocellular carcinoma tumor growth and metastasis[J]. Hepatology, 2015, 61(2):561-573.
【16】Sun HT, Cheng SX, Tu Y, et al. FoxQ1 promotes glioma cells proliferation and migration by regulating NRXN3 expression[J]. PLoS One, 2013, 8(1):e55693.
【17】Vishnubalaji R, Hamam R, Yue S, et al. MicroRNA-320 suppresses colorectal cancer by targeting SOX4, FOXM1, and FOXQ1[J]. Oncotarget, 2016, 7(24):35789-35802.
【18】Christensen J, Bentz S, Sengstag T, et al. FOXQ1, a novel target of the Wnt pathway and a new marker for activation of wnt signaling in solid tumors[J]. PLoS One, 2013, 8(3):e60051.
【19】Peng X, Luo Z, Kang Q, et al. FOXQ1 mediates the crosstalk between TGF-beta and Wnt signaling pathways in the progression of colorectal cancer[J]. Cancer Biol Ther, 2015, 16(7):1099-1109.
【20】Xia L, Huang W, Tian D, et al. Forkhead box Q1 promotes hepatocellular carcinoma metastasis by transactivating ZEB2 and VersicanV1 expression[J]. Hepatology, 2014, 59(3):958-973.
【21】Bao B, Azmi AS, Sarkar FH. Pancreatic cancer stem-like cells display aggressive behavior mediated via activation of FoxQ1[J]. J Biol Chem, 2014, 289(21):14520-14533.
【22】Liang SH,Yan XZ,Wang BL,et al. Increased expression of FOXQ1 is a prognostic marker for patients with gastric cancer[J].Tumour Biol, 2013, 34(5):2605-2609.
【23】Xiang XJ, Deng J, Liu YW, et al. MiR-1271 inhibits cell proliferation, invasion and EMT in gastric cancer by targeting FOXQ1[J]. Cell Physiol Biochem, 2015, 36(4):1382-1394.
【24】Feng J, Zhang XS, Zhu HJ, et al. FoxQ1 overexpression influences poor prognosis in non-small cell lung cancer, associates with the phenomenon of EMT[J/OL]. PLoS One, 2012, 7(6):e39937.
【25】Feng J, Xu L, Ni S, et al. Involvement of FoxQ1 in NSCLC through regulating EMT and increasing chemosensitivity[J]. Oncotarget, 2014, 5(20):9689-9702.
【26】张甦, 邢建明, 钱净. 宫颈癌中Foxq1与NF-κBp65的表达及临床病理意义[J]. 第二军医大学学报, 2009, 30(3):300-304.
【27】Wang W, He S, Ji J, et al. The prognostic significance of FOXQ1 oncogene overexpression in human hepatocellular carcinoma[J]. Pathol Res Pract, 2013, 209(6):353-358.
【28】Huang W, Chen Z, Shang X, et al. Promotes hepatocellular carcinoma metastasis through up-regulating Twist1 and FGFBP1[J]. Hepatology, 2015, 61(2):1920-1933.
【29】Zhang H, Meng F, Liu G, et al. Forkhead transcription factor foxq1 promotes epithelial-mesenchymal transition and breast cancer metastasis[J]. Cancer Res, 2011, 71(4):1292-1301.
【30】Sehrawat A, Kim SH, Vogt A, et al. Suppression of FOXQ1 in benzyl isothiocyanate-mediated inhibition of epithelial-mesenchymal transition in human breast cancer cells[J]. Carcinogenesis, 2013, 34(4):864-873.
【31】Ross JB, Huh D, Noble LB, et al. Identification of molecular determinants of primary and metastatic tumour re-initiation in breast cancer[J]. Nat Cell Biol, 2015, 17(5):651-664.
【32】Kim SH, Kaschula CH, Priedigkeit N, et al. Forkhead box Q1 is a novel target of breast cancer stem cell inhibition by diallyl trisulfide[J]. J Biol Chem, 2016, 291(26):13495-13508.
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